Active freeze drying

The Active Freeze Dryer (AFD) is a patented technology of Hosokawa Micron B.V. The technology enables the freeze drying of pharmaceutical drug substances via sublimation at low pressures in a jacketed vessel. A screw-arm motion gently agitates the frozen substance continuously while a vacuum pump is used to evacuate air and vapor from the chamber. To aid sublimation, energy is indirectly introduced to the frozen substance via the jacketed wall of the vessel.


This project aims to study the AFD process via small scale experiments using a representative sample material. The focus is to deepen our understanding of pressure and temperature variation during the freeze drying process. Particularly, pressure variation in the dryer will be studied and proposals for process optimisation will be made.  To carry out the experiments, a transparent piece with fittings that allows connections for temperature and pressure probes have been designed and fabricated.

For this project, you will have access to Hosokawa Micron’s testing facility and also support from experienced process technologists and engineers.

Good to know: the assignment is written down in English but doesn’t have to be! You can do it in Dutch as well.

Hosokawa Micron

Hosokawa Micron is a global supplier of process equipment and systems for the powder and bulk processing industries. It has developed a wide range of innovative drying and cooling technologies meeting your requirements for drying of powder or paste. The most important features are: leading company in its industry, inspiring work environment, focus on service and committed to the customers wishes. Hosokawa Micron B.V. in Doetinchem provides all different kind of processes, from engineering to production, customer service and its own testing laboratories. With approximately 160 employees they are established in Doetinchem, a city about 35 km from Arnhem.  

Would you like to get in touch? 

Did you get excited reading the assignment above or have some questions? Please contact Judith Anvelink, manager of Innovatiehub Doetinchem. You can do this via email: or on the phone: +31630403115.

Active freeze drying
  • Hosokawa Micron
  • Gildenstraat 26
  • 7005 BL Doetichem
  • Innovatiehub Doetinchem
Active freeze drying
  • Vakgebieden Chemische Technologie
  • Opleidingsniveau HBO/WO
  • Soort Stage Meeloop-/afstudeerstage
  • Innovatiehubmanager Judith Anvelink
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